Small Molecule Bioanalysis

When searching for the hard-to-find molecule, gaining insights and expertise from the DMPK community is critical. Browse these resources to be even more effective in quantifying small molecules for drug efficacy.

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What's New? Microfluidic Separation Devices Coupled to MS

In this publication, the utilization of chip-based separation devices coupled to MS for analyzing peptides/proteins, glycans, drug metabolites and biomarkers for various bioanalytical applications are evaluated.

The Ever-Expanding Role of HRMS in Regulated Bioanalysis

Dr. Chris Evans (Director Bioanalytical Sciences and Toxicokinetics, GSK) showcases case studies where HRMS facilitated adaptable bioanalytical study support to: overcome challenges associated with selectivity; understand molecular integrity; and facilitate intact analysis.

Achieving Femtogram-level On-column Sensitivity for Quantitation of Drugs in Human Plasma

Advances in HRMS have led to improved selectivity, dynamic range, linearity, and sensitivity, In the presence of complex matrix interferences that might prove challenging for triple quadrupole MS approaches, the markedly different nature of HRMS data acquisition can achieve the selectivity and sensitivity for successful quantitation.

High Throughput Analysis with Microfluidics Under Gradient Conditions

The ionKey/MS System with Xevo G2-XS Qtof HRMS is a high-performance platform that can be used for highly sensitive detection of small molecules, peptides, and proteins. This application shows the ionKey/MS can also be operated under high throughput conditions with a 3-minute full gradient and a 7 μL/min flow rate.

Exploring the Versatility of Microflow Technology from Peptide Biomarkers to Small Molecules

The use of microfluidic technology for peptide quantitation yields the same or better sensitivity when compared to a nanoscale platform and has the additional, very significant advantages of ease of use, robustness, and improved chromatographic resolution (e.g. peak capacity). Thus, with a single analytical platform we can perform quantitative analysis for a wide range of compounds spanning from small molecules to peptides.

Is Ion Mobility Mass Spectrometry Child's Play?

Waters is making ion mobility as easy to use as your cell phone or your remote control. Take a look at this blog describing the merits of ion mobility for routine mass spectrometry.

Bridging the Gap…Connecting Evolving Bioanalysis Expertise to a Rapidly Changing Global Biopharma Industry

As the pharmaceutical industry continues to shift more toward biologics and hybrid drug entities, it becomes increasingly imperative that the small and large molecule bioanalysis worlds work together to efficiently arrive at go/no-go decisions. This webinar will address these trends as well as the impact on drug development and regulatory requirements for drug approval.

Are Analytical Chemists Going Extinct?

In this blog, the idea of an 'endangered' analytical chemists is explored. They face a myriad of obstacles today – lower than average job forecasts, costly and timely training, demand for more versatile knowledge, tighter regulations, and massive data management requirements. What do you think?

Analysis of Corticosteroids and Androgens in Serum for Clinical Research

An analytically sensitive and selective clinical research method has been developed for the analysis of testosterone, androstenedione, 17-OHP, DHEAS, cortisol, 11-deoxycortisol, and 21-deoxycortisol in serum using the Xevo TQ-S micro.

Quantitative Analysis of Dried Bloodspot 17-Hydroxyprogesterone by ACQUITY UPLC-MS/MS for Clinical Research

In this application note a method for the extraction and UPLC-MS/MS analysis of DBS 17-OHP using the ACQUITY UPLC System with the Xevo TQ MS Detector is described.