Small Molecule Bioanalysis

When searching for the hard-to-find molecule, gaining insights and expertise from the DMPK community is critical. Browse these resources to be even more effective in quantifying small molecules for drug efficacy.

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A Forensic Toxicology Analysis of Synthetic Fentanyl Compounds in Whole Blood Using Oasis Prime MCX and Waters TQ-S Micro

This poster was presented at the 2018 ASMS annual conference from June 3-7 in San Diego, CA.

A Clinical Research Method for the Analysis of Serum Testosterone and Androstenedione

An analytically sensitive and selective clinical research method has been developed for the analysis of serum testosterone and androstenedione.

Analysis of Serum Adrenal Steroids Using the ACQUITY UPLC I-Class with Xevo TQD for Clinical Research

This technology brief demonstrates the analytically sensitive and precise measurement of adrenal steroids from limited-volume clinical research serum samples.

Multiplexed Analysis of Steroid Hormones Using ionKey/MS

In this application, we report the use of the newly developed 150-μm ionKey/MS System for the multiplexed quantitation of five steroid compounds in human serum.

Analysis of Testosterone, Androstenedione, and Dehydroepiandrosterone Sulfate in Serum for Clinical Research

This application note describes a clinical research method utilizing Oasis PRiME HLB μElution Plate technology for the extraction of testosterone, androstenedione, and DHEAS from serum.

Analysis of 17-Hydroxyprogesterone in Serum for Clinical Research

An analytically sensitive and selective clinical research method has been developed for the analysis of 17-OHP in serum. Using only 100 μL sample volume, this method provides sufficient analytical sensitivity to analyze low physiological levels of 17-OHP.

Quantitative Analysis of Dried Bloodspot 17-Hydroxyprogesterone by ACQUITY UPLC-MS/MS for Clinical Research

In this application note a method for the extraction and UPLC-MS/MS analysis of DBS 17-OHP using the ACQUITY UPLC System with the Xevo TQ MS Detector is described.

Analysis of Serum Cortisol, Androstenedione, and 17-hydroxyprogesterone Using 2D UPLC-MS/MS for Clinical Research

In this technology brief, a method for the analysis of serum cortisol, androstenedione, and 17-hydroxyprogesterone was successfully developed on an ACQUITY UPLC I-Class with 2D Technology with a Xevo TQD. A simple protein precipitation followed by separation using an ACQUITY UPLC BEH C18 SB VanGuard™ Pre-column in the first dimension and an ACQUITY UPLC HSS T3 Column in the second dimension was used to selectively clean the serum sample to provide optimum analytical performance.

Analysis of Testosterone Using the Xevo TQ-XS for Clinical Research

This technology brief demonstrates the high analytical sensitivity and quantitative performance of the Xevo® TQ-XS for the analysis of serum testosterone for clinical research using 100 μL serum.

Analysis of Plasma 17-Hydroxyprogesterone, Androstenedione, and Cortisol

Sample preparation is an important consideration for any bioanalytical LC-MS/MS method for clinical research. Waters has developed a novel sample preparation sorbent, Oasis® PRiME HLB, which is designed to have some key advantages over traditional SPE sorbents.