Small Molecule Bioanalysis

When searching for the hard-to-find molecule, gaining insights and expertise from the DMPK community is critical. Browse these resources to be even more effective in quantifying small molecules for drug efficacy.

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CDMO Pushes Bioanalytical Boundaries with Innovative Topical and Transdermal Services

In this case study learn how MedPharm is successful in its innovative approach to topical and transdermal product design and development services by utilizing Waters bioanalytical instrumentation and software solutions.

A Rapid Method for The Ultra-Sensitive Quantification of Fluticasone Propionate and Salmeterol Xinafoate from Human Plasma

This high-throughput method achieves the lowest published LLOQ's for fluticasone propinate (0.1 pg/mL) and salmeterol (0.05 pg/mL).

A Forensic Toxicology Analysis of Synthetic Fentanyl Compounds in Whole Blood Using Oasis Prime MCX and Waters TQ-S Micro

This poster was presented at the 2018 ASMS annual conference from June 3-7 in San Diego, CA.

The Versatility of Microflow LC/MS – Making High Sensitivity Applications More Routine with ionKey/MS

Originally launched in response to the need for robust, high sensitivity microflow LC/MS applications, the integrated microfluidic tile-based ionKey/MS™ platform continues to evolve as a system that can be implemented for routine applications. ionKey/MS™ has quickly gained traction in new application spaces yielding a more functional and flexible system. These new areas include quantification of intact and digested monoclonal antibodies, thyroglobulin, opioids in oral fluid, estradiol, and steroids.

Top ten misconceptions about microflow LC/MS

You’ve heard a lot about microflow LC/MS. Are you cautious about making the switch? Do you still have questions or concerns about method development? We are going to use this time to review the top 10 misconceptions and challenges that we have heard and observed. Our hope is that after you have listened to this presentation, you will be able to make an informed decision on how microflow LC/MS will fit into your workflow.

A Sensitive Microflow LC/MS/MS Method for the Analysis of Fluticasone Propionate in Human Plasma

This poster presented at 65th ASMS Conference from June 4-8 in Indianapolis, IN.

An HS-MRM Assay for Quantification of Host Cell Proteins in Therapeutic Monoclonal Antibodies

This poster presented at 65th ASMS Conference from June 4-8 in Indianapolis, IN.

Data Independent and Data Dependent Acquisition Strategies Combined With Ion Mobility for Drug Metabolism and Pharmacokinetics

This poster presented at 12th Annual Great Lakes DMDG meeting from May 4-5th in Michigan.

Peer reviewed literature for microflow LC-MS
August 2017

The following is a compendium of microflow LC-MS-based peer reviewed journal articles using Waters® ionKey/MS™ System. Each article is authored by leading researchers and/or Waters’ scientists. They cover many analytes of interest including small and large molecule therapeutics, biomarkers, supplements, and food.

High Throughput Microflow LC-MS: Sensitivity Gains on a Practical Timescale

The sensitivity gains observed when using microflow LC-MS do not always translate into an everyday workflow advantage in a high throughput laboratory. The longer run times that are typical on a microflow scale deliver improved sensitivity, but decreased sample throughput when compared to UPLC. The ability to deliver high sensitivity at run times under 3 minutes compelled the need to develop a microflow device that can function on a UPLC timescale (<3 min).

This white paper introduces a novel microfluidic device capable of higher pressures and flow rates which enable run times under 3 minutes while still delivering improved sensitivity over traditional UPLC systems.