This technical note demonstrates the ability of QuanRecovery Sample Plates with MaxPeak HPS (High Performance Surfaces) to mitigate non-specific binding of monoclonal antibody biotherapeutics and improve analytical method performance.
This application note aims to describe the process of developing a successful, automated capture and digestion method for hybrid LC-MS/MS quantification of the fusion protein, etanercept.
This application note presents a highly sensitive and selective sample preparation strategy for the LC-MS/MS quantification of free/active biotherapeutic from human serum for the TNF-α targeting biotherapeutics: infliximab, adalimumab, and etanercept.
In this work, we have a developed a complete sample preparation and LC-MS/MS workflow for the sensitive and accurate quantification of salmon calcitonin from human serum.
This poster demonstrates HRMS sensitivity of intact level quantification for three monoclonal antibodies, adalimumab, infliximab, and trastuzumab prepared through affinity purification in mouse plasma.
Tim Sikorski - GlaxoSmithKline Interview
Tim Sikorski, Investigator - Exploratory Biomarkers, discusses his role at GlaxoSmithKline and how Waters has contributed to his work.
Tim Sikorski - Practical Approaches to Protein Biomarker Quantification by LC-MS - PEGS 2018
Tim Sikorski, Investigator-Exploratory Biomarkers at GlaxoSmithKline, discusses Practical Approaches to Protein Biomarker Quantification by LC-MS at PEGS 2018.
This application note describes a simple sample preparation strategy using Oasis WCX μElution SPE combined with analytical flow LC and a tandem (triple) quadrupole MS for the high sensitivity quantification of salmon calcitonin from human serum.