Peptide and Protein Bioanalysis Boot Camp
Building Proficiency in LC-MS Large Molecule Quantification
Waters’ team of bioanalysis experts developed the Peptide & Protein Bioanalysis Boot Camp – a series of short, recorded presentations – to help you and your colleagues acquire a fundamental and practical proficiency in large molecule quantification.
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Integrated Microflow LC-MS for Peptide & Protein Quantification
In this module, Waters' Market Development Manager, Logan Umberger explains how to apply microflow LC-MS in your large molecule bioanalysis efforts.
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An Introduction to High Resolution Mass Spectrometry versus Tandem Quad Mass Spectrometry for Large Molecule Bioanalysis
This presentation, presented by Ian Edwards, is designed as a primer for those new to mass spec and want to apply it to large molecule bioanalysis. It also appeals to those using triple quad MS and are exploring the benefits of HRMS for quantification of challenging samples.
Ian has a doctorate in the application of mass spectrometry and stable isotope labelling to measure protein turnover in animals, and in his early career as an application specialist in industry worked with MALDI-TOF MS systems for protein identification, molecular imaging and microbial identification. Ian spent several years in the Waters European Applications Laboratory working on a range of high resolution mass spectrometry applications including metabolomics, proteomics, molecular imaging and large molecule bioanalysis (therapeutics and biomarkers) before moving into marketing roles at a regional and global level. In his current business role he is focused on the application of LC-MS for large molecule bioanalysis including the emerging area of intact protein quantification.
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High Resolution Mass Spectrometry: Introduction to Quantitative Data Acquisition Modes on a Waters QTof for Large Molecule Bioanalysis
Hear from Mark Wrona as he discusses this next module in a series of training presentations discussing LC-MS–based quantification for large molecules using high resolution mass spectrometers.
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Case Studies in High Resolution Mass Spectrometry (HRMS) for Large Molecule Bioanalytical Quantification
In this presentation, Caitlin Dunning demonstrates the sensitivity and selectivity that can be achieved with HRMS for the quantification of peptides and proteins, speaks to some of the practical considerations to keep in mind for successful method development and more.
Caitlin received her bachelor’s in Chemistry from Northeastern University (Boston, MA) where she participated in their signature cooperative education program. Leveraging her co-op experiences into a full-time position, Caitlin started her career in the field of proteomics. In this position, she learned that she loved bioanalytical chemistry, especially mass spectrometry. Caitlin joined Waters in 2016 as an Associate Applications Scientist where she provides support for new product development and discovery bioanalysis of proteins and peptides. She is responsible for all aspects of method development, including sample preparation, liquid chromatography, and mass spectrometry. She enjoys working on solutions to challenging bioanalytical applications and sharing her work with customers.
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High Resolution Mass Spectrometry for Quantification of Intact Monoclonal Antibodies in Plasma
In this short presentation we will go over an introduction to intact level protein quantification using LC-MS, then we will cover some of the challenges and best practices associated with this application and more.
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Developing an Automated Platform for Standardized, Large Molecule Bioanalysis
The hybrid immunoaffinity capture and surrogate peptide digest approach is an established method for LC-MS based protein quantification. However, this complex workflow is not easily implemented and requires a high level of expertise. Steven Calciano, Senior Product Manager, discusses how automation of a broadly applicable sample preparation method can address the increasing analytical demand for large molecule DMPK studies and improve laboratory efficiency.
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